How the concurrent serum measurements of FAI will correspond to the ER-β/ER-α ratio may be still one of conjecture, but, based on the medical knowledge gained in research, it is expected that a decreased FAI level will correspond directly to the ER-β/ER-α ratio. The ER-β/ER-α ratio is expected to be elevated in diseases that have a predilection for women such as Lupus Erythematosus and breast cancer. These ratios are still untested in the majority of disease, but, they are expected to be depressed in both men and women with cardiovascular disease, adult diabetes and other chronic diseases that have relatively equal distribution between men and women. There is gender difference: The ER-β/ER-α ratio is strongly elevated in endometriosis and depressed in IBD. Bioavailable testosterone is measured in the serum as the Free Androgen Index (FAI) the ratio of total testosterone (TT) to sex-hormone-binding globulin (SHBG). Bioavailable testosterone is necessary for normal function of the Androgen Receptor (AR), Estrogen Receptor (ER) and aromatase activity. For Gender Specific Medicine (GSM) now supersedes symptomatic treatments such as adalimumab in Inflammatory Bowel Disease, leuprolide acetate in endometriosis and corticosteroids in many autoimmune diseases, because GSM addresses causation.ĮR-β/ER-α is a highly specific biomarker for inflammation that can be measured in the T-lymphocytes in the blood. The ER-β/ER-α ratio has become one of the two key biomarkers for physicians and researchers to identify, analyze, and treat within this Gender Specific Medicine (GSM) specialty. Not until the gastroenterologist realized that a decrease in the ER-β/ER-α ratio strongly correlated with flairs in Crohn's Disease did the significance of the Estrogen Receptors take hold of the Gender Specific Medicine hierarchy. The gynecologists, as Gender Specific Medicine specialists for women, noted a profound 100-fold increase in the Estrogen Receptor-β/Estrogen Receptor-α ratio in proliferative endometriosis tissue. Gender Specific Medicine started as an observational medical subspecialty that traverses all fields of health care. Remission may be attainable with even the most resistant Crohn's and Ulcerative Colitis patients as observed in the Case Reports. Admixtures of anabolic steroids should reset the biomarkers and reduce the autoimmune, inflammatory, and systemic aspects of disease. Here is the future of medicine: After initial medical information intake, measure Gender Specific Medicine biomarkers of gonadal hormones (causation) and then treat to normalize these biomarkers. Five inexpensive, generic, FDA approved anabolic steroid medications have been successfully used to treat IBD, albeit, not the recognized standard of care. Causation is clearly demarcated to hormonal dysregulation at the Hypothalamic-Pituitary-Gonadal Axis suppressing testosterone production. The second being bioavailable testosterone measured as the Free Androgen Index. There are now serum hormonal biomarkers that are highly predictive of flairs in Crohn's diseases the first being the nuclear membrane Estrogen Receptor-beta/Estrogen Receptor-alpha ratio. The problems to date in understanding and treating IBD are that no one has identified the cause, no specific biomarkers are recognized, no alternatives to overtly toxic medications and no alternatives exist for inevitable surgical resections. Adalimumab's failure rate is 40 percent by year two, 60 percent by year five, and the 12-year German study questions whether there is any long-term gain in quality of life at all. Adalimumab, the last pharmaceutical TNF-inhibitor drug approved for IBD was 17 years ago. New cases in the youngest quadrille are appearing at a 0.5 percent rate per year. Two-hundred thousand young men and women in North America will have major bowel resection annually, half to experience a premature death and many an increased risk of colorectal cancer. Five Anabolic Steroids in the Treatment of Inflammatory Bowel DiseaseĬrohn's disease (CD) and ulcerative colitis (UC), the constituents of Inflammatory Bowel Disease (IBD), are the most destructive benign diseases of young adults.
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That will send audio to the Firestudio driver and to the mixer ‘digital in’ stereo channel. On a Mac, one needs to use Audio/Midi Setup.app to change the output channels to the last two channels and not the first two. I am using a computer that has never been setup for audio or the 32RM Ai. So it thinks it’s not registered, when it definitely IS.Įdit: A couple of things. Also, the mixer doesn’t connect with the website anymore. Yes, I do have Presonus Firestudio selected in sound prefs. I updated my RM32 AI firmware and software to the latest versions and now I don’t get connected via FireWire at all. It is a shame that I cannot run the current versions for the RM, my laptop and iPad.  For now I'll stick with what I have set up, but I would be really leery of moving forward. Doesn't appear that they are really supporting their customers as they have in the past. The way I see it is that older software worked better, new software doesn't work as well and PreSonus have all but given up trying to make new software work as well as the old. I'd be so pleased for Presonus to enter into dialogue even but I get the picture they're just big kids going 'la,la,la' with their fingers in their ears. I asked support ages ago about updates to the firmware and I was simply told that they couldn't comment. I suspect that a key software developer has left the organisation and there are no longer the in-house skills to fix a system that is riddled with bugs. I’m equally happy to question your integrity, credibility and reliability in as many public forums possible. PreSonus, I’m happy to take this discussion offline. My equipment is no longer fit for purpose. I think there are probably legal grounds for a full refund on the equipment I have invested in, based on the action of the manufacturer rendering it inoperable and unfit for purpose within a reasonable life span. I feel disillusioned by a company that I have put trust in and am starting to question its integrity. It’s such a pity that my relatively modern mixer has been rendered inoperable by software ‘updates’ from the company that made the thing. I firmly believe that PreSonus have chosen to turn a blind and ignorant eye to the issues. We have spent money on their products and they have all but broken them for us. I'm mostly incensed that Persons remain silent despite out unhappiness. Here are some of the end comments from various people who've been lining your pockets. Christ, I'm from darkest Africa and I think you should move your HQ here, so that future potential investors in your product, can be warned about "the after sales" failures. Can some fuckhead from Presonus get off your fat bleep and answer these above issues. The present city walls, the Citadel, some mosques and tombs survive from the Middle Ages, but the greatest part of the built heritage of the city dates from after the Ottoman conquest of the early 16th century.Ĭriterion (i): Damascus testifies to the unique aesthetic achievement of the civilizations which created it. However, apart from the incomparable Great Mosque, built on the site of a Roman temple and over-laying a Christian basilica, there is little visible dating from this important era of the city's history. The city was the capital of the Umayyad Caliphate. The earliest visible physical evidence dates to the Roman period - the extensive remains of the Temple of Jupiter, the remains of various gates and an impressive section of the Roman city walls. Thus the city today is based on a Roman plan and maintains the aspect and the orientation of the Greek city, in that all its streets are oriented north-south or east-west and is a key example of urban planning. In spite of Islam's prevailing influence, traces of earlier cultures particularly the Roman and Byzantine continue to be seen in the city. In particular, the Umayyad caliphate created Damascus as its capital, setting the scene for the city's ongoing development as a living Muslim, Arab city, upon which each succeeding dynasty has left and continues to leave its mark. The city exhibits outstanding evidence of the civilizations which created it - Hellenistic, Roman, Byzantine and Islamic. In the Medieval period, it was the centre of a flourishing craft industry, with different areas of the city specializing in particular trades or crafts. However, it is not documented as an important city until the arrival of the Aramaeans. Excavations at Tell Ramad on the outskirts of the city have demonstrated that Damascus was inhabited as early as 8,000 to 10,000 BC. The old city of Damascus is considered to be among the oldest continually inhabited cities in the world. Founded in the 3rd millennium B.C., Damascus was an important cultural and commercial centre, by virtue of its geographical position at the crossroads of the orient and the occident, between Africa and Asia. There are secondary errands for you to complete, but these often slap an arbitrary time limit on the endeavour, or force you to plough through a specific number of corpses in return for monetary bonuses.Ĭash can be invested in vehicle upgrades, but the game stops you from grinding your way to the best goodies by forcing you to unlock them first. Sadly, the campaign’s variety doesn’t live up to its scope, with most objectives finding you driving to different locations and relieving them of the undead. In single-player, you’re challenged with 31 different missions, each set in a huge open-world environment. Unfortunately, while it’s easier to navigate your vehicle in this setting, the constant twitchiness of the camera can be nauseating, especially when you’re moving fast. The former set-up is loose and gets stuck behind the scenery, meaning that you have no choice but to plump up for the latter. The action takes place from an isometric perspective, with two camera options to choose from: ‘Smart’ attempts to predict your movements, while ‘Static’ changes perspective as you turn the wheel. The gameplay fares better, but is flawed in key areas. You will garner some fun out of trying to guess which accent the budget performers are trying to ape, but that soon wears out its welcome when you realise that you can’t skip conversation sequences in-game. Despite the digital download’s talkative tone, there’s very little substance to the narrative aside from shoddy dialogue and terrible voice acting. The title does attempt to weave a conspiracy plot around its blood-soaked premise, but you probably won’t pay too much attention to it. Armed with an expanding garage of everyday vehicles and access to the government’s secret stash of lethal artillery, you embark upon a campy adventure in which you attempt to get to the bottom of your home town’s undead predicament. You fill the overalls of a survivor in a corpse-crammed suburban city. It results in a braindead isometric zombie slayer which sadly lacks the bite of its subject matter. At least it should be, but EXOR Studios’ matter-of-fact PlayStation Network racer Zombie Driver HD gets its wheels in a spin in some crucial areas. Guts, guns, and gasoline: it’s a match consummated in the underworld. Nowadays, most Japanese people understand the meaning of the word meccha however, it is mostly the younger generations that use it. People thought the word was funny and quaint. It is an adjective that means “confused incoherent disorderly chaotic.” However, in modern times, Japanese people living in Kansai (an area of Japan with a distinctive dialect) have shortened mecha kucha to meccha and now use it as an ad verb to mean “insanely” or “crazy.” When comedians from the Kansai region started appearing regularly on national TV and using meccha, the phrase became more and more popular in Tokyo and other regions of Japan. Meccha (めっちゃ) originates from the word めちゃくちゃ ( mecha kucha). Think about it like your mom saying that the salad dressing at Restaurant X is “totally lit” vs. Adult females use it too among their close friends and family, but it’s not as cool when adults say it. Today, however, we’re going to focus on how to use it in conversation.Ĭhou, when used in conversation as an ad verb to mean “totally” or “absolutely,” is used predominantly by young females. It is used for trains to indicate a super-express (超特急, choutokkyuu), or it can even be used for camera film to indicate that it is ultra-sensitive (超高感度フィルム, choukoukando firumu). The one on the left is 走 ( sou), meaning to “run.” The one on the top right is 刀 ( tou), meaning “sword,” “saber,” or “knife.” And the one on the bottom right is 口 ( kou), meaning “mouth.” Put all of these radicals together and you get the kanji 超!Ĭhou is used in a variety of situations. Let’s take a closer look at the kanji for chou to see how it took on these meanings.Ĭhou is made up of three different radicals. If you look up the word “ chou” in the dictionary, you will find definitions like “super-,” “ultra-,” or perhaps “uber-” (alright I guess that one’s a bit dated…). Instead of saying something is 「とても美味しい,」 we’re going to say it’s 「超美味しい」( “chou oishii,” “super delicious”). Now that we know how to use “ totemo” in Japanese, it’s time to slang it up a bit. The comedian we saw yesterday was so funny! Kinou mita komedian wa totemo omoshirokatta ne! Totemo is also used when the speaker is speaking to people unknown to them and to people with whom they want to make a good impression on and keep a good relationship with. It is mainly used by people who are out of school and deal with other adults, superiors, and bosses on a daily basis. It is used in both casual and formal speech. Totemo is an ad verb that describes adjectives. Think of it like saying something is 「とても美味しい」( “Totemo oishii,” “really good”) vs.「とっても美味しい」( “Tottemo oishii,” “really REALLY good”). The difference between the two is that the latter places more emphasis. You can also add an extra T in the center of totemo to make it tottemo (とっても). The most textbook way of saying “very” in Japanese is by using the word totemo (とても). Today, we’re going to learn three different levels of “very” in Japanese using the words “ totemo, ” “ chou, ” and “ meccha. It’s REALLY oishii ! But, no, wait, it’s not just REALLY oishii, it’s GOD-IN-YOUR-MOUTH oishii ! “ Oishii !” (“This is so delicious!”) you want to say, but it’s not just oishii. Totemo(とても), Chou(ちょう), Meccha(めっちゃ) : Japanese Common Phrases That Mean “Very” 1 Totemo(とても), Chou(ちょう), Meccha(めっちゃ) : Japanese Common Phrases That Mean “Very”. Terminal/console same thing being loose with my definition hereītw the & is universal to any command at the bash prompt. list-encodings: Display list of possible values for the encoding. a text editor gedit FILE & Opens (or creates) FILE in gedit. Set the character encoding to be used for opening the files listed on the command line. To install emacs editor open terminal (By CTRL+ALT+T) and execute the. 1) Open the terminal 2) Go to the directory where you want the text file. Example: open -a 'Adobe Photoshop CC 2014' /Desktop/test.psd. If you want to open any file with a specific application, just enter: open -a 'Application' /Path/to/file. If you are not used to terminal text editor, maybe you can tryout the GUI text. We can edit files by different Linux editors like vim, nano, Emacs, Gedit, Gvim. Just to complete this answer: With timotyhm's command you will open the file with the default application for this filetype. This raw mode is really done on the tty device which is attached to the console/terminal window and is commonly done when using a serial port to transfer files to another device (the binary data contains control-c and other bytes that can cause problems The Terminal app is the command line interface for Linux, where you run programs by. Another way of editing the file is using a mousepad which is a GUI text editor. Programs like VI (terminalbased) puts the console in raw mode so that vi can detect you typed keys like control-Z or control-C (normally control-c kills your app) The fg is the foreground it wll wakeup the gedit window and hag the terminal window The terminal will say something and start working again From normal user terminal, I run xhost + to grant access to all user temporarily Then I log in as root from a different terminal and execute the X-app ie gedit tester. In order to make MOV files more compatible with other platforms, many users are converting MOV to MP4 format. Many multimedia players don’t support MOV files also you have to install a compatible player to play it on Android devices. This video container is used to play videos on Mac-based systems. Elmedia Player 7. MOV on the other hand is QuickTime multimedia file format, or in simple terms, it is the default format for QuickTime media player. You don’t need a specific media player to play MP4 files since it is compatible with all major media players across every platform. MP4 is a compressed file format which means that the format occupies less memory space and provides stunning video experience to the users. It supports all major devices and operating systems. vlcplayer convert mp3 technique TECHNIQUEDREAMTD mediaplayer How to convert WAV to MP3 file format Using VLC media player FILE WAV MP3. From the downloading videos feature, right to extracting audio, everything offered in the Pro version makes it well worth the 9.99 you shell out for it. Click on the Document icon to add MKV files you need to play after downloading and installing Wondershare UniConverter. MP4 format is used widely for online streaming of multimedia files like videos, audios, etc. Elmedia Player is an exceptionally well made media player for Mac as it is, but the Pro version really comes in as a delight for one’s day to day needs. Easy steps to convert and play MKV files easily with Wondershare UniConverter: Step 1: Add MKV videos that need to play. But, before we get to the actual process, let’s compare some primary features and limitations of MOV and MP4 media containers. In this write up, we will discuss some free-methods to convert your MOV video files to formats like MP4, AVI, FLV, etc. You can carry out the migration easily with the help of online or offline converter tools. Multiple formats supported including FLV, SWF, XAP, AVI, MOV, etc.A direct approach to solve this compatibility issue is to convert MOV files to formats supported by major devices and operating systems. Playback enhancement options (A-B loop, 10-band audio equalizer with presets, video and image layout adjustments, etc.) Make screenshot of a movie moment or convert the whole video to screenshots Ad banners, as well as embedded video and audio players are created with this technology too. SWF format originated with FutureWave Software, then transferred to Macromedia, and is currently Adobe product.Īdobe Flash is a multimedia software platform used to create animations, rich Internet applications, web presentations, games, etc. It is a very popular Flash media file format widely used for Flash animation based on vector & raster graphics, as well as for Flash menus, buttons, banners. These formats are used by most popular video websites as YouTube, VEVO, Hulu, Metacafe, Yahoo! Video, etc. Both of them are developed by Adobe Systems. Two different video file formats are known as Flash video – FLV & F4V. The encoding manner for the audio & video data within these video files is the same as within SWF files. Lightweight VLC Media Player consumes less device resources compared to similar apps. Download Elmedia Player The download is free of charge. Clean My Mac Final Cut Pro x Logic Pro X Serial Box. It can play pretty much any file type, be it AVI, MP4, FLV, Home Applications. It is possible to open MP4 file with almost any player on Windows but on Mac you should use a plug-in or just convert the file to another format. It is a container that supports all kinds of media such as video, audio, subtitles, 2D and 3D graphics. Flash Video is used for delivery of video over the web with the help of Adobe Flash Player version 6 and later. 278 alternatives to VLC Media Player VLC is a free and open source cross-platform multimedia player and framework that plays most multimedia files as well as DVDs, Audio CDs, VCDs, and various streaming protocols. Elmedia Video Player Pro 7.7 (MAS) Elmedia Video Player Pro 7.7 (MAS) Elmedia Video Player is a free media player for Mac OS. MP4 is an extension defined by MPEG-4 video standard and AAC audio standard. See, the game, through no real fault of its own, can get pretty repetitive. Once you get through the main tutorial section though, Mushroom Wars 2 starts to reveal why it likely released for more casual platforms like iOS, tvOS, and Switch far before it released for PS4 and Xbox, what I played it on. The game gives you the abilities at a tutorial level, but a couple of the abilities are a little hard to grasp and in my opinion, the game is a little more fun without needing to worry about them. Mushroom Wars 2 also introduces leader abilities that allow you to do a handful of other things such as move troops faster and automatically take your opponent’s buildings with no troops in them, but the abilities can get a little hard to track, and the game does not explain them very well, either. Instead, you often need to set up and execute large-scale attacks against all of your opponent’s buildings at once. On larger maps, in particular, you will need to move and place your troops in strategically good positions, but just taking one building at a time often might not work. Because you and your opponent have the same setup, in order to win, especially on harder difficulties, you have to rely on a pretty good balance of solid strategy and quick movements. This really points to the game’s core mechanic. Neutral buildings are often easier to capture, though attacking your opponent’s buildings can harm them and put you in a more advantageous position. You can either capture your opponent’s buildings or you can capture neutral buildings, occupied by neither you nor your opponent. Speaking of the enemies, the game’s maps often, but not always, feature a perfectly symmetrical layout (or close to it), starting you and your opponent off in the same scenario. The most basic kind of building will generate troops over time, so capturing these buildings not only increases your troops’ amount and capacity but also increases the rate at which you can get new troops, though the buildings do have caps on how many troops they will create.Īs the game progresses, you will quickly unlock the ability to control how many troops you send from one building to the other, in addition to a handful of other buildings, such as a forge that increases your troops’ attacking ability (though I never fully understood what the game meant by that) and turrets that will shoot at enemy troops as they move through a set radius around it. The game’s early stages have you move little mushroom troops from building to building, capturing them as you go. The game’s campaign starts you out very simply, with just basic troop movement mechanics. |
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