![]() ![]() How the concurrent serum measurements of FAI will correspond to the ER-β/ER-α ratio may be still one of conjecture, but, based on the medical knowledge gained in research, it is expected that a decreased FAI level will correspond directly to the ER-β/ER-α ratio. The ER-β/ER-α ratio is expected to be elevated in diseases that have a predilection for women such as Lupus Erythematosus and breast cancer. These ratios are still untested in the majority of disease, but, they are expected to be depressed in both men and women with cardiovascular disease, adult diabetes and other chronic diseases that have relatively equal distribution between men and women. ![]() There is gender difference: The ER-β/ER-α ratio is strongly elevated in endometriosis and depressed in IBD. ![]() Bioavailable testosterone is measured in the serum as the Free Androgen Index (FAI) the ratio of total testosterone (TT) to sex-hormone-binding globulin (SHBG). Bioavailable testosterone is necessary for normal function of the Androgen Receptor (AR), Estrogen Receptor (ER) and aromatase activity. For Gender Specific Medicine (GSM) now supersedes symptomatic treatments such as adalimumab in Inflammatory Bowel Disease, leuprolide acetate in endometriosis and corticosteroids in many autoimmune diseases, because GSM addresses causation.ĮR-β/ER-α is a highly specific biomarker for inflammation that can be measured in the T-lymphocytes in the blood. The ER-β/ER-α ratio has become one of the two key biomarkers for physicians and researchers to identify, analyze, and treat within this Gender Specific Medicine (GSM) specialty. Not until the gastroenterologist realized that a decrease in the ER-β/ER-α ratio strongly correlated with flairs in Crohn's Disease did the significance of the Estrogen Receptors take hold of the Gender Specific Medicine hierarchy. The gynecologists, as Gender Specific Medicine specialists for women, noted a profound 100-fold increase in the Estrogen Receptor-β/Estrogen Receptor-α ratio in proliferative endometriosis tissue. Gender Specific Medicine started as an observational medical subspecialty that traverses all fields of health care. Remission may be attainable with even the most resistant Crohn's and Ulcerative Colitis patients as observed in the Case Reports. Admixtures of anabolic steroids should reset the biomarkers and reduce the autoimmune, inflammatory, and systemic aspects of disease. Here is the future of medicine: After initial medical information intake, measure Gender Specific Medicine biomarkers of gonadal hormones (causation) and then treat to normalize these biomarkers. Five inexpensive, generic, FDA approved anabolic steroid medications have been successfully used to treat IBD, albeit, not the recognized standard of care. ![]() Causation is clearly demarcated to hormonal dysregulation at the Hypothalamic-Pituitary-Gonadal Axis suppressing testosterone production. The second being bioavailable testosterone measured as the Free Androgen Index. There are now serum hormonal biomarkers that are highly predictive of flairs in Crohn's diseases the first being the nuclear membrane Estrogen Receptor-beta/Estrogen Receptor-alpha ratio. The problems to date in understanding and treating IBD are that no one has identified the cause, no specific biomarkers are recognized, no alternatives to overtly toxic medications and no alternatives exist for inevitable surgical resections. Adalimumab's failure rate is 40 percent by year two, 60 percent by year five, and the 12-year German study questions whether there is any long-term gain in quality of life at all. Adalimumab, the last pharmaceutical TNF-inhibitor drug approved for IBD was 17 years ago. New cases in the youngest quadrille are appearing at a 0.5 percent rate per year. Two-hundred thousand young men and women in North America will have major bowel resection annually, half to experience a premature death and many an increased risk of colorectal cancer. Five Anabolic Steroids in the Treatment of Inflammatory Bowel DiseaseĬrohn's disease (CD) and ulcerative colitis (UC), the constituents of Inflammatory Bowel Disease (IBD), are the most destructive benign diseases of young adults. ![]()
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